This tender and juicy slow cooker meatloaf is packed with flavor, perfectly seasoned, and topped with a tangy glaze. It’s a comforting classic made easier with the help of your slow cooker!
Ingredients
For the Meatloaf:
- 2 pounds ground beef (80/20 or 85/15 works best)
- 1 cup breadcrumbs (plain or seasoned)
- 1/2 cup milk
- 2 large eggs
- 1/2 cup grated Parmesan cheese
- 1 small onion, finely chopped
- 2 cloves garlic, minced
- 1 tablespoon Worcestershire sauce
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 1 teaspoon Italian seasoning (optional)
For the Glaze:
- 1/2 cup ketchup
- 2 tablespoons brown sugar
- 1 tablespoon Dijon mustard

Instructions
Step 1: Prepare the Meatloaf
- In a large bowl, combine ground beef, breadcrumbs, milk, eggs, Parmesan cheese, onion, garlic, Worcestershire sauce, salt, pepper, and Italian seasoning.
- Mix gently with your hands until just combined—avoid overmixing to keep the meatloaf tender.
- Shape the mixture into a loaf and place it on a piece of parchment paper or aluminum foil.
Step 2: Set Up the Slow Cooker
- Place the loaf into the slow cooker, keeping it on the parchment paper or foil for easy removal.
- Cover and cook on low for 6–8 hours or on high for 3–4 hours, until the internal temperature reaches 160°F (71°C).
Step 3: Make the Glaze
- In a small bowl, whisk together ketchup, brown sugar, and Dijon mustard.
- During the last 30 minutes of cooking, spread the glaze over the meatloaf. Cover and continue cooking.
Step 4: Serve and Enjoy
- Carefully lift the meatloaf out of the slow cooker using the parchment paper or foil. Let it rest for 5–10 minutes before slicing.
- Serve with mashed potatoes, roasted vegetables, or a crisp salad.
Notes
- Make Ahead: You can prepare the meatloaf mixture the night before and store it in the refrigerator until ready to cook.
- Customizations: Add shredded carrots or zucchini for extra moisture and nutrients. Swap ground beef for ground turkey for a leaner option.
- Storage: Store leftovers in an airtight container in the refrigerator for up to 3 days or freeze for up to 3 months.
Nutrition (Per Serving):
- Calories: 420
- Protein: 30g
- Fat: 25g
- Carbohydrates: 18g
- Sodium: 720mg
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